YMCbasic

superior separation of basic compounds alternative bonding approach to reduce peak tailing of basic pharmaceuticals no need for ion pair reagents or amine modifiers complementing selectivity to C8 and C18 materials

General

YMC created in 1988, yet still having fully up-to-date technology, a new bonded phase for the separation of basic pharmaceuticals and similar compounds by bringing together a support containing neutral silanol groups, which have minimal interactions with acidic and basic compounds, and a novel bonded phase consisting of monomerically bonded alkyl chains. The proprietary derivatisation procedure for YMCbasic allows YMC to produce a material with controlled surface coverage, which shows excellent lot-to-lot reproducibility as a result of closely monitoring both the production of the silica support and the bonding process.
The resulting YMCbasic material shows a different hydrophobicity compared with C8 or C18 phases as shown in the diagram. In addition, it also represents an interesting alternative to short chain selectivities.

Properties

YMCbasic is a phase with true reversed phase characteristics, high resolution and excellent peak symmetry for basic compounds without the need for ion pair reagents or amine modifiers (see separation of anilines using acetonitrile/water eluent). Unlike many base-deactivated phases, YMCbasic is also suitable for separation of acidic compounds, showing slight retention of highly polar acid compounds such as maleate. YMCbasic provides a complementing selectivity seen with conventional C8 and C18 materials, but without peak tailing for basic compounds.