YMC*Gel C8 (Octyl)

alternative phase to C18 with moderate hydrophobicity fully endcapped, high coverage monomeric bonded chemistry ideal for method development and routine separations excellent retention for all types of organic molecules, especially peptides, proteins and pharmaceuticals

General

YMC*Gel C8 is one of YMC’s most commonly used bonded phases and an excellent alternative to C18 selectivities. Due to its moderate hydrophobicity YMC*Gel C8 is well suited for the separation of hydrophobic compounds which are too strongly retained on C18 phases or for samples that require greater retention than provided by C4 packings. Compared to C18 phases, retention times of non-polar compounds will be lower on C8 material due to the reduced carbon load.

Properties

YMC*Gel C8 is prepared by exhaustive bonding of a monomeric octylsilane to YMC’s totally spherical and porous silica gel. The functionalised silica is then treated with a thorough endcapping process. This produces a moderate 10% carbon loading on the standard 12 nm pore material.

Available in three porosities, 12, 20 and 30nm, YMC*Gel C8 packings will separate many classes of compounds including pharmaceuticals, organic chemicals, peptides, proteins and other biological molecules, making it ideal for method development. For optimum yield in preparative applications, choose the smallest pore size which provides adequate retention and resolution. This is because sample loading is generally proportional to surface area. Smaller pore packings provide greater surface area and hence greater loadability.